Route 666: Three Strikes, You're Out is a Call of Cthulhu 7th Edition scenario set in 1950s America. Players are Black Investigators making a road trip from Chicago to California, along the famous Route 66 highway. The first stop is St. Louis, where the Cardinals are playing a new team to the league, the Kingsport Kings. The scenario is a mix of real-world Black history and the fantastic monsters of H.P. Lovecraft. The scenario includes 4 character sheets that enable players to jump right into the game, and a suggested playlist of songs from the era.